Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2006-12-20
2009-02-24
Gambel, Phillip (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S130100, C424S133100, C424S141100, C424S152100, C424S158100, C530S387100, C530S387300, C530S388200, C530S388240
Reexamination Certificate
active
07494651
ABSTRACT:
The present invention provides very high affinity antibodies, or antigen-binding fragments thereof, that neutralize mature human TGF-β1, TGF-β2, and TGF-β3. The antibodies of the invention are useful for treating cell proliferative disorders in a mammal.
REFERENCES:
patent: WO2005/097832 (2005-10-01), None
Carlsson, et al., “n-CoDer concept: Unique Types of Antibodies for Diagnostic Use and Therapy,”Expert Review of Molecular Diagnostics 1(1):102-108 (2001).
Carruthers, et al., “In vitro and in vivo characterization of CAT-192 and 1D11: Neutralising antibodies to transforming growth factor beta,”British Journal of Pharamcology 135(Proceedings Supp.):265p (Mar. 2002).
Hoefer, et al., “Anti-(Transforming Growth Factor Beta) Antibodies with Predefined Specificity Inhibit Metastasis of Highly Tumorigenic Human Xenotransplants in Nu/Nu Mice,”Cancer Immunology and Immunotherapy 41(5):302-308 (1995).
Shah, et al., “Neutralisation of TGF-Beta1 and TGF-Beta2 or Exogenous Addition of TGF-Beta3 to Cutaneous Rat Wounds Reduces Scarring,”Journal of Cell Science 108(Part 3):985-1002 (1995).
Wolleheim, et al., “Sixth International Workshop on Scleroderma Research,”Arthritis Research 33:34-40 (2001).
PCT International Search Report for PCT/US2006/062397, mailed May 7, 2007.
Jones Bryan Edward
Pancook James D.
Rowlinson Scott William
Cohen Charles E.
Congping Xie
Eli Lilly and Company
Gambel Phillip
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