Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-05-23
1999-12-28
Fitzgerald, David L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435325, 435356, 435365, 4352523, 4353201, 536 235, 536 2431, C12N 1512, C07K 1471, C07K 14715
Patent
active
060080116
ABSTRACT:
The mammalian TGF-.beta. type II receptor has been cloned. Nucleic acids encoding full-length and soluble receptor polypeptides, as well as fragments of such nucleic acids useful as probes, are provided. Corresponding vectors, transformed host cells, and their use to produce recombinant TGF-.beta. receptors are also described.
REFERENCES:
Goergi, L. L., et al., (1990) Cell 61: 635-645.
Nikawa, J. (1994) Gene 149: 367-372.
Suzuki, A., et al., (1994) Febs Lett. 355: 19-22.
Massague, et al., "Cellular Receptors for Type Beta Transforming Growth Factor", J. Biol. Chem., 260(5):2636-2645 (1985).
Massague, J., "Subunit Structure of a High-affinity receptor for Type Beta-transforming Growth Factor", J. Biol. Chem., 260 (11) :7059-7066 (1985).
Cheifeitz, S. et al., "Cellular Distribution of Type I and Type II Receptors for Transforming Growth Factor-Beta*", J. Biol. Chem., 261(21):9972-9978 (1986).
Fanger, B.O., et al., "Structure and Properties of the Cellular Receptor for Transforming Growth Factor Type Beta", Biochem., 25:3083-3091 (1986).
Cheifetz, S., et al., "The Transforming Growth Factor-Beta System, a Complex Pattern of Cross Reactive Ligands and Receptors", Cell, 48:409-415 (1987).
Ignotz, R.A., et al., "Cell Adhesion Protein Receptors as Targets for Transforming Growth Factor-Beta Action", Cell, 51:189-197 (1987).
Segarini, P.R., et al., "The High Molecular Weight Receptor to Transforming Growth Factor-Beta Contains Glycosaminoglycan Chains", J. Biol. Chem., 263 (17):8366-8370 (1988).
Chiefetz, S. et al., "The Transforming Growth Factor-Beta Receptor Type III is a Membrane Proteoglycan", J. Biol. Chem., 263 (32):16984-16991 (1988).
Chiefetz, S. et al., "Transforming Growth Factor-Beta (TGF-Beta) Receptor Proteoglycan", J. Biol. Chem., 264(20):12025-12028 (1989).
Andres, J. L., et al., "Membrane-anchored and Soluble Forms of Betaglycan, a Polymorphic Proteoglycan that Binds Transforming Growth Factor-Beta", J. Cell. Biol., 109:3137-3145 (1989).
Massague, J., "The Transforming Growth Factor-Beta Family", Annu. Rev. Cell. Biol., 6:597-641 (1990).
Massague, J., et al., "TGF-Beta Receptors and TGF-Beta Binding Proteoglycans: Recent Progress in Identifying Their Functional Properties", Ann. NY Acad. Sci., 593:59-72 (1990).
Laiho, M. et al., "Responsiveness to Transforming Growth Factor-beta (TGF-Beta) Restored by Genetic Complementation between Cells Defective in TGF-Beta Receptors I & II", J. Biol. Chem., 266(14):9108-9112 (1991).
Lin, H.Y., et al., "Expression Cloning of the TGF-Beta Type II Receptor, a Functional Transmembrane Serine/Threonine Kinase", Cell, 68:775-785 (1992).
Wrana, J.L., et al., "TGF-.alpha. Signals through a Heteromeric Protein Kinase Receptor Complex", Cell, 71, in press., Dec. 11 issue (1992).
O'Grady, P., et al., "Expression of a New Type High Molecular Weight Receptor (Type V Receptor) of Transforming Growth Factor .alpha. in Normal and Tranformed Cells," Biochemical and Physical Research Communications 179 (1):378-385 (1991).
Lopez-Casillas, F. et al., "Structure and Expression of the Membrane Proteoglycan Betaglycan, a Component of the TGF-.alpha. Receptor System," Cell 67:785-795 (1991).
Wang, X. et al., "Expression Cloning and Characterization of the TGF-.alpha. Type III Receptor, " Cell 67:797-805 (1991).
Cheifetz, S., et al., "Distinct Transforming Growth Factor-.alpha. (TGF-.alpha.) Receptor Subsets as Determinants of Cellular Responsiveness to Three TGF-.alpha. Isoforms," The Journal of Biological Chemistry 265(33):20533-20538 (1990).
Cheifetz, S., et al., "Transforming Growth Factor-.alpha. Receptor Type III Is a Membrane Proteoglycan," J. of Biol. Chem. 263(32):16984-16991 (1988).
Massague, J., et al., "TGF-.alpha. Receptors and TGF-.alpha. Binding Proteoglycans: Recent Progress in Identifying Their Functional Properties," Annals of the N.Y. Acad. of Sci. 593:59-72 (1990).
Lin Herbert Y.
Lodish Harvey F.
Wang Xiao-Fan
Weinberg Robert A.
Fitzgerald David L.
Whitehead Institute for Biomedical Research
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