Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1994-04-28
1997-01-28
Allen, Marianne P.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424423, 424426, 424484, 514 12, 514 21, 530350, 530356, 530399, A61K 900, A61K 910, A61K 3818, A61K 3839
Patent
active
055975780
ABSTRACT:
Antiproliferative compositions are provided which are capable of sustained release of an antiproliferative agent, particularly a TGF-.beta., at a site proximal to a target cell. The compositions are effective in inhibiting proliferation of the target cell, particularly when used in combination with a vasoconstrictive agent.
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Mustoe et al., 1987, "Accelerated Healing of Incisional Wounds in Rates Induced by Transforming Growth Factor-.beta.", Science 237: 1333-1336.
Pierce et al., Jul. 1989, "Platelet-Derived Growth Factor and Transforming Growth Factor-.beta. Enhance Tissue Repair Activities by Unique Mechanisms", J. Cell. Biol. 109: 429-440.
Derynck et al. J. Biol Chem 261(10): 4377-4379 (1986).
Brown Dennis M.
Luck Edward
Purchio Anthony F.
Twardzik Daniel R.
Allen Marianne P.
Matrix Pharmaceuticals
Oncogen
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