Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1992-05-04
1995-08-22
Draper, Garnette D.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 691, 530399, C07H 1512
Patent
active
054441641
ABSTRACT:
A new TGF-.beta. induced gene and protein is described. Treatment of TGF-.beta. growth arrested cells induces the production of a novel gene which encodes a 683 amino acid protein, designated BIG-H3, that contains four homologous repeat regions and which may represent a cell surface recognition molecule. This gene and protein is induced in mammalian cells, and specifically human cells, upon treatment with TGF-.beta., and is shown to inhibit the growth of tumor cells.
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Neubauer Michael G.
Purchio Anthony F.
Skonier John E.
Bristol--Myers Squibb Company
Cermak Shelly Guest
Draper Garnette D.
Sorrentino Joseph M.
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