TGF-beta binding antibodies

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

Reexamination Certificate

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Details

C424S130100, C424S133100, C424S141100, C424S152100, C424S158100, C530S387100, C530S387300, C530S388200, C530S388240

Reexamination Certificate

active

07927593

ABSTRACT:
The present invention provides very high affinity antibodies, or antigen-binding fragments thereof, that neutralize mature human TGF-β1, TGF-β2, and TGF-β3. The antibodies of the invention are useful for treating cell proliferative disorders in a mammal.

REFERENCES:
patent: 7494651 (2009-02-01), Jones et al.
patent: 2005/097832 (2005-10-01), None
Carlsson, et al., “n-CoDer concept: Unique Types of Antibodies for Diagnostic Use and Therapy,” Expert Review of Molecular Diagnostics 1(1): 102-108 (2001).
Carruthers, et al, “In vitro and in vivo characterization of CAT-192 and ID11: Neutralising antibodies to transforming growth factor beta,” British Journal of Pharmacology 135(Proceedings Supp.);265p (Mar. 2002).
Hoefer, et al., “Anti-(Transforming Growth Factor Beta) Antibodies with Predefined Specificity Inhibit Metastasis of Highly Tumorigenic Human Xenotransplants in Nu/Nu Mice,” Cancer Immunology and Immunotherapy 41(5):302-308 (1995).
Shah, et al., “Neutralisation of TGF-Beta1 and TGF-Beta2 or Exogenous Addition of TGF-Beta3 to Cutaneous Rat Wounds Reduces Scarring,” Journal of Cell Science 108(Part 3):985-1002 (1995).
Wolleheim, et al., “Sixth International Workshop on Scleroderma Research,” Arthritis Research 3:34-40 (2001).
Padua et al., Cell Research 19: 89-1 02, 2009.
Varga et al., Curr Opin Rheumatol 20: 720-728, 2008.
Khan, Cardiology 108: 368-380, 2007.

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