TGF.beta.1 responsive bone marrow derived cells to express a rec

Details TGF.beta.1 responsive bone marrow derived cells to express a rec TGF.beta.1 responsive bone marrow derived cells to express a rec

1996-11-12

2000-05-16

Crouch, Deborah

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 696, 435 704, 435402, C12P 2106, C12P 2104, C12N 502

Patent

active

060635932

ABSTRACT:
A method for expressing a recombinant protein from bone marrow-derived cells comprises the steps of treating the bone marrow-derived cells in vitro with a TGF.beta.1 protein, which selects a population of the cells for further treatment. The selected cells can then be expanded, after which a gene encoding a therapeutic protein can be inserted into the expanded cells and thereafter express the therapeutic protein. The transduced cells can then be introduced into a mammal to produce a therapeutic result.

REFERENCES:
patent: 5486359 (1996-01-01), Caplan et al.
Hao et al (1995) Human Gene Therapy 6, 873-880.
Gordon et al., "Capture of bone marrow-derived human mesenchymal stem cells with a transforming growth factor .beta.1 (TGF.beta.1) fusion protein: implications for gene therapy for hemophilia B" Blood, vol. 86, supp. 1, p. 998a (Dec. 1995).
Mizuno et al., "TGF-beta accelerated the oestogenic differentiation of bone marrow cells induced by collagen matrix" Biochemical and Biophysical Research Communications, vol. 211, No. 3, pp. 1091-1098 (Jun. 26, 1995).
Crystal (1995) Science 270, 404-410.

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