Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-02
1996-12-24
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514 2, 514 6, 514 28, 514 43, 514 44, 514 81, 514410, 530345, 5303913, 5303915, 530405, 534 11, 534 13, 534 15, 534 16, 536 171, 536 173, 540145, 540465, 540472, A61K 31715, C07D48722
Patent
active
055873715
ABSTRACT:
Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutralizing hydroxyl radicals, allowing hydroxyl radicals to cause cellular damage, ii) a relatively stable texaphyrin radical that reacts readily to covalently modify neighboring molecules causing further cellular damage, iii) intrinsic biolocalization, and iv) indifference to the presence or absence of O.sub.2. These properties allow texaphyrins to be particularly effective for treating the hypoxic areas of solid neoplasms. Methods of treatment for an individual having a neoplasm or atheroma include the use of a texaphyrin as a radiation sensitizer and as an agent for photodynamic tumor therapy, or the use of a texaphyrin for internal and for external ionizing radiation. Novel texaphyrins are provided.
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Hemmi Gregory W.
Kr al Vladimir A.
Magda Darren
Mody Tarak D.
Sessler Jonathan L.
Board of Trustees, Univ. of TX Sys.
Larson Jacqueline S.
Pharmacyclics Inc.
Raymond Richard L.
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