Tetronic acid derivative

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C536S007100, C435S117000

Reexamination Certificate

active

10852766

ABSTRACT:
The present inventors intended to search for substances that can regulate the expression of a molecular chaperone, GRP78, using the expression of GRP78 as an indicator. As a result, a novel tetronic acid derivative, versipelostatin compound (also known as JL68) shown in formula (I) having the activity of suppressing GRP78 expression was isolated from the metabolite ofStreptomyces versipellisstrain 4083-SVS6. Versipelostatin can be obtained from the culture supernatant by culturing the above-mentionedStreptomyces versipellisstrain 4083-SVS6

REFERENCES:
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patent: WO 02/12945 (2002-02-01), None
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