Tetrazolylphenyl pivalate derivatives and medicinal composition

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548253, C07D25704, A61K 3141

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active

056021615

ABSTRACT:
The tetrazolylphenyl pivalate of the the following general formula or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 and R.sup.2 each represents a hydrogen atom, a lower alkyl group or other substituents; an elastase-inhibitory composition, a composition for preventing and treating emphysema and a composition for preventing and treating endotoxin-induced lung disorders each comprising the foregoing tetrazolylphenyl pivalate derivative or a non-toxic or acid-addition salt thereof.

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Tetsuya Hirano, et al., "A New Synthetic Elastase Inhibitor, EI-546, Protects Lungs but Not Pancreas in Caerulein-Induced Pancreatistis in the Rat", Med. Sci. Res., 1992, pp. 473-474.
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