Tetrazolyl-substituted pyrido[1,2-a]pyrimidines and use as SRS-A

Details Tetrazolyl-substituted pyrido[1,2-a]pyrimidines and use as SRS-A Tetrazolyl-substituted pyrido[1,2-a]pyrimidines and use as SRS-A

1986-10-01

1989-03-28

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544282, C07D47104, A61K 31505

Patent

active

048164593

ABSTRACT:
Pyrido[1,2-a]pyrimidine derivatives of the general formula [I] and their physiologically acceptable salts are provided: ##STR1## where R is a hydrogen atom, a halogen atom or a methyl group, and n is a whole number of 0, 1 or 2. The pyrido[1,2-a]-pyrimidine derivatives and their salts exhibit an excellent antagonistic effect on slow-reacting substance of anaphylaxis and, therefore, are useable for the treatment of allergic diseases.

REFERENCES:
patent: 4122274 (1978-10-01), Juby
patent: 4192944 (1980-03-01), Juby
patent: 4209620 (1980-06-01), Juby
patent: 4474953 (1984-10-01), Wade
patent: 4617407 (1986-10-01), Young et al.
patent: 4667055 (1987-05-01), Gillard et al.
Finnegan et al., J. Amer. Chem. Soc., vol. 80, 3908-3911 (1958).

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