Tetrazolyl compounds and their use as anti allergic agents

Details Tetrazolyl compounds and their use as anti allergic agents Tetrazolyl compounds and their use as anti allergic agents

1984-07-11

1987-06-23

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548251, 548252, 558 10, 558405, 558410, C07C12152, C07C16102, C07D25704, A61K 3141

Patent

active

046753346

ABSTRACT:
Compounds of formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently selected from H, OH, C.sub.1 -C.sub.4 alkyl, R.sub.4 --CO and halogen, where R.sub.4 is C.sub.1 -C.sub.4 alkyl; R.sub.5 and R.sub.6 are each independently selected from H, C.sub.1 -C.sub.4 alkyl and optionally-substituted phenyl; R.sub.7 is an alkylene group having from 1 to 4 carbon atoms, optionally containing a substituted or unsubstituted phenyl group; p is 0 or 1; and Z is a 1H-tetrazol-5-yl or a --CN group; and salts thereof, may be prepared by reacting a compound of formula. ##STR2## with a compound of formula ##STR3## wherein R.sub.1 -R.sub.7 are as defined in claim 1, in an organic solvent at a temperature in the range of 40.degree.-120.degree. C. in the presence of a base, and reacting the resulting compound with an alkali metal cyanide or thiocyanate, and optionally reacting the resulting compound with a source of azide ions to produce pharmacologically active compounds of formula I wherein Z is 1H-tetrazol-5-yl.

REFERENCES:
patent: 3972934 (1976-08-01), Marshall
Chemical Abstracts 88:152148j (1978) Abstracting Oelschlaeger et al.
Mann et al., J. Chem. Soc., 2819 (1954).
Buckle et al., J. Med. Chem., 22(2), 158 (1979).

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