Tetrazoleacetic acid derivatives having aldose reductase inhibit

Details Tetrazoleacetic acid derivatives having aldose reductase inhibit Tetrazoleacetic acid derivatives having aldose reductase inhibit

1992-01-16

1993-10-12

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548253, A61K 3141, C07D25704

Patent

active

052525929

ABSTRACT:
A tetrazoleacetic acid derivative represented by the following general formula (I): ##STR1## [in Formula (I), R.sub.1 represents a hydrogen atom or a lower alkyl group; R.sub.2, R.sub.3 and R.sub.4 are the same or different from each other and are selected from the group consisting of hydrogen, lower alkyl, halogen, lower haloalkyl, hydroxy and lower alkoxy; and tetrazol group is substituted at 1- or 2-position of naphthyl group] except for [5-(1-naphthyl)tetrazol-1-yl]acetic acid and ethyl ester thereof, or a salt thereof.

REFERENCES:
patent: 3453285 (1969-07-01), Hayal et al.
Chem. Abstracts, vol. 110, No. 13; 114728p (1989).
C. R. Jacobson et al., "Tetrazolylacetic Acids and Esters," Studies in Tetrazole Chemistry. IV, vol. 21, Mar. 1956, pp. 311-316.

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