Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-09-11
1998-01-20
McKane, Joseph
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514255, 514326, 514340, 514381, 514382, 544132, 544366, 546210, 5462684, 548253, A61K 31535, C07D41306
Patent
active
057101531
ABSTRACT:
A tetrazole derivatives of formula (I) ##STR1## a non-toxic salt thereof, an acid addition salt thereof or a hydrate thereof which has an inhibitory effect on interleukin-1.beta. converting enzyme (ICE).
REFERENCES:
patent: 5434248 (1995-07-01), Chapman et al.
Dinarello & Woff, "The Role of Interleukin-1 Disease", The N.E. J. Med., 328:2:106-113, (1993).
Campion et al., "Dose-Range and Dose-Frequency Study of Recombinant Human Interleukin-1 Receptor Antagonist in Patients with Rheumatoid Arthritis", Arthr. & Rheumatism, 39:7:1092-1101, (1996).
Mjalli et al., "Inhibition of Interleukin-1.beta. Converting Enzyme by N-Acyl-Aspartyl Aryloxymethyl Ketones", Bioorg. & Medicinal Chem. Ltrs., 5:13:1409-1414, (1995).
Miyazaki Tohru
Ohmoto Kazuyuki
Ohno Hiroyuki
Tanaka Makoto
McKane Joseph
Ono Phramaceutical Co., Ltd.
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