Tetravalent bispecific receptors, the preparation and use thereo

Details Tetravalent bispecific receptors, the preparation and use thereo Tetravalent bispecific receptors, the preparation and use thereo

1994-09-21

1999-09-28

Eisenschenk, Frank C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303899, 5303883, 530866, 530869, 5303897, 5303871, 435 7021, 4351722, 4352533, 4353201, 435 697, 4351885, 4241301, 4241331, 4241341, 4241351, 4241431, 4241551, 4241741, C07K 1646, A61K 31395, C12N 1513

Patent

active

059590831

ABSTRACT:
The invention relates to bispecific tetravalent receptors of the formula I ##STR1## or formula II ##STR2## against a tumor-associated antigen and against an agent active against tumors.

REFERENCES:
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K. Bosslet et al.; "Generation of Bispecific Monoclonal Antibodies for Two Phase Radioimmunotherapy"; British Journal of Cancer, vol. 63, No. 5, May 1991, pp. 681-686.
J. Le Doussal et al.; "Targeting of Indium 111-labeled Bivalent Hapten to Human Melanoma Medieated By Bispecific Monoclonal Antibody Conjugates: Imaging of Tumors Hosted in Nude Mice"; Cancer Research, vol. 50, No. 11, Jun. 1990, pp. 3445-3452.
H. Paulus, Preparation and Biomedical Applications of Bispecific Antibodies, Behring Inst. Mitteilungen, (1985), No. 78, pp. 118-132.
Uwe D. Staerz and Michael J. Bevan, hybrid hybridoma producing a bispecific monoclonal antibody that can focus effector T-cell activity, Proc. Natl. Acad. Sci. USA, vol. 83, pp. 1453-1457, Mar. 1986.
J. van Dijk et. al., Induction of Tumor-Cell Lysis Bi-Specific Monoclonal Antibodies Recognizing Renal-cell Carcinoma and CD3 Antigen, Int. J. Cancer: 43, (1989), pp. 344-349.
Rosaria Orlandi et. al., Cloning immunoglobulin vairiable domains for expression by the polymerase chain reaction, Proc. Natl. Acad. Sci. USA, vol. 86, pp. 3833-3837, May 1989.
Frank Lee et.al., Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumour virus chimaeric plasmids, Nature, vol. 294, pp. 228-232, Nov. 19, 1981.
Hudziak et al.; Establishment of Mammalian Cell Lines Containing Multiple Nonsense Mutations and Functional Suppressor tRNA Genes, Cell, vol. 31, pp. 137-146, Nov. 1982.
Biochim. Biophys. Acta Protein Struct. Mol. Enzymol. (Netherlands) 1990, 1040/1 (1-11) Nolan et al.

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