Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-11-03
1988-11-01
Gron, Teddy S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514352, 546309, 546255, 546257, 544360, 544390, A01N 4340, C07D23902
Patent
active
047820713
ABSTRACT:
Certain tetrasubstituted alkyl, aryl, pyridinyl, piperidinyl, and piperazinyl urea compounds stimulate the release of acetylcholine and are thus useful analgesic agents for alleviating pain or as cholinergic agents which are useful for the amelioration of the symptoms of cognitive decline in the elderly.
These compounds have the general formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.4 are phenyl or substituted phenyl, and R.sub.3 is pyridinyl.
Pharmaceutical compositions including these compounds as well as methods for the preparation of the compounds are also disclosed.
REFERENCES:
patent: 3904602 (1975-09-01), Somlo
patent: 4058392 (1977-11-01), Thomas et al.
patent: 4083814 (1978-04-01), Mark et al.
patent: 4088653 (1978-05-01), Knaus et al.
patent: 4349526 (1982-09-01), Goor et al.
patent: 4425208 (1984-01-01), Jacobine
patent: 4428923 (1984-01-01), Kunkel et al.
patent: 4444863 (1984-04-01), Sano et al.
patent: 4446247 (1984-05-01), Jacobine
patent: 4472583 (1984-09-01), Clifford
patent: 4473579 (1984-09-01), Devries et al.
patent: 4518473 (1985-05-01), Jacobine
patent: 4551562 (1985-11-01), Drauz et al.
patent: 4564514 (1986-01-01), Drauz et al.
patent: 4628126 (1986-12-01), Drauz et al.
patent: 4694004 (1987-09-01), Nakaguti et al.
Chappelow, C. C. et al., J. Chem. Eng. Data 11 (3), pp. 436-442 (1966).
Butler Donald E.
Lustgarten David M.
Moos Walter H.
Thomas Anthony J.
Caress Virginia B.
Daignault Ronald A.
Gron Teddy S.
Warner-Lambert & Company
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