Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines a

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546201, A61K 3144

Patent

active

057983682

ABSTRACT:
Tetrasubstituted 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF.alpha. in a mammal. A typical embodiment is 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline.

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patent: 5385901 (1995-01-01), Kaplan et al.
patent: 5502666 (1996-03-01), Heinemann et al.
patent: 5593990 (1997-01-01), D'Amato

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