Tetrapyrrole therapeutic agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 2, 540145, A61K 3140, C07D48722

Patent

active

046753389

ABSTRACT:
The present invention relates to compounds having the following formula: ##STR1## or the corresponding di- or tetrahydrotetrapyrroles wherein ##STR2## provided that when R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.7 and R.sub.8 represent two substituents or are divalent and attached to the same carbon, the respective pyrrole ring to which attached is a dihydropyrrole;

REFERENCES:
patent: 4393071 (1983-07-01), Fujii et al.
Cariello et al, Chemical Abstracts, vol. 90 (1979) 83836j.
Ballantine et al, Chemical Abstracts, vol. 93 (1980) 183058n.
Selve et al, Chemical Abstracts, vol. 95 (1981) 132,845a.
Jackson et al, Chemical Abstracts, vol. 97 (1982) 144645q.
Tsvetkov et al, Chemical Abstracts, vol. 101 (1984) 110,106a.
Fukuda et al, Chemical Abstracts, vol. 102 (1984) 122538y.
Chemical Berischte, 90, 470-481, 1957, by Lautsch, et al.
Hoppe-Seyler's Ztschr. Phy Chem., 327, 205-216, 1962, by Losse and Muller.
Chimia, 13, 129-180, 1959, by Karrer.
Tetrahedron Letters, 23, 2017-2020, 1978, by Pelter, et al.
Current Microbiology, 8, 195-199, 1983, by Gauthier, et al.
Zhurnal Organicheshoi Kiii Mii, 15, 828-835, 1979 by Bacunbee, et al.
Dougherty, et al., Journal of the National Cancer Institute, 55, 1976 pp. 115-119.
Wile, et al. "Laser Photoradiation Therapy of Recurrent Human Breast Cancer and Cancer of the Head and Neck," in Porphyrin Photosensitization, ed. by Kesser and Dougherty, Alan R. Liss, Inc., New York, N.Y., pp. 47-52 (1973).
Lin, et al., "HpD Photodetection of Bladder Carcinoma," in Porphyrin Localization and Treatment of Tumors, ed. by Doiron and Gomer, Alan R. Liss, Inc. New York, N.Y. pp. 187-199 (1984).
Aizawa, et al., "A New Diagnostic System for Malignant Tumors Using Hematoporphyrin Derivative, Laser Photoradiation and a Spectroscope," in Porphyrin Localization and Treatment of Tumors, ed. by Dorion and Gomer, Alan R. Liss, Inc., New York, N.Y., pp. 227-238 (1984).
Henderson, et al., "Studies on the Mechanism of Tumor Destruction by Photoradiation Therapy," in Porphyrin Localization and Treatment of Tumors, ed. by Dorion and Gomer, Alan R. Liss, Inc., New York, N.Y., pp. 601-612 (1984).
Hayata, et al., "Indications of Photoradiation Therapy in Early Stage Lung Cancer on the Basis of Post-PRT Histologic Findings," in Porphyrin Localization and Treatment of Tumors, ed. by Dorion and Gomer, Alan R. Liss, Inc., New York, N.Y., pp. 747-758 (1984).
Profio, et al., "Fluorescence of Hematoporphyrin-Derivative for Detection and Characterization of Tumors", in Porphyrins in Tumor Photo-therapy, ed. by Andreoni and Cubeddu, Plenum Press, New York, N.Y., pp. 321-337 (1984).
Benson, Ralph C., "The Use of Hematoporphyrin Derivative (HpD) in the Localization and Treatment of Transition Cell Carcinoma (TCC) of the Bladder," in Porphyrin Localization and Treatment of Tumors, ed. by Dorion and Gomer, Alan R. Liss, Inc., New York, N.Y., pp. 795-804 (1984).
Fioretti, et al., "Monitoring of Hematoporphyrin Injected in Humans and Clinical Prospects of Its Use in Gynecologic Oncology," in Porphyrins in Tumor Phototherapy, ed. by Andreoni and Cubeddu, Plenum Press, New York, N.Y., pp. 355-361 (1984).
Doiron, et al., "Hematoporphyrin Derivative Photoradiation Therapy of Endobronchial Lung Cancer," in Porphyrins in Tumor Phototherapy, ed. by Andreoni and Cubeddu, Plenum Press, New York, N.Y., pp. 395-403 (1984).
Spinelli, et al., "Endoscopic HpD-Laser Photoradiation Therapy (PRT) of Cancer," in Porphyrins in Tumor Phototherapy, ed. by Andreoni and Cubbeddu, Plenum Press, New York, N.Y., pp. 423-426 (1984).
Ohi, et al., "Photoradiation Therapy with Hematoporphyrin Derivative and an Argon Dye Laser of Bladder Carcinoma," in Porphyrins in Tumor Phototherapy, ed. by Andreoni and Cubbeddu, Plenum Press, New York, N.Y., pp. 439-446 (1984).
Bruce, R. A., Jr., "Photoradiation for Chorodial Malignant Melanoma," in Porphyrins in Tumor Phototherapy, ed. by Andreoni and Cubbeddu, Plenum Press, New York, N.Y., pp. 455-461 (1984).
Berenbaum, et al., "In Vivo Biological Activity of the Components of Haematoporphyrin Derivative", in Br. J. Cander pp. 571-581 (1982).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Tetrapyrrole therapeutic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tetrapyrrole therapeutic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tetrapyrrole therapeutic agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-721520

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.