Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-11-09
1993-12-28
Bond, Robert T.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
540452, 540454, C07D48129, C01B 1300, C01B 3118
Patent
active
052740900
ABSTRACT:
Disclosed is a metalloporphyrin-ligand complex which includes (a) a meso-tetraphenylporphyrin, (b) a crown ether rigidly attached to the meso-tetraphenylporphyrin by covalent attachment on one side of the porphyrin to two diagonally opposing phenyl groups, (c) a metal bound to the pyrrole nitrogens of the porphyrin, (d) a bridge covalently linking two diagonally opposing phenyl groups on the other side of the porphyrin, effective to hinder .mu.-oxo diner formation, and (e) a ligand having (i) a primary amine which is held noncovalently by the crown ether and (ii) a metal-coordinating atom which is coordinately bound to the metal.
In another aspect, the invention includes a water-soluble oxygen carrier. The oxygen carrier includes a meso-.alpha.,.alpha.,.alpha.,.alpha.-tetrakis(o-propanoylamino)phenylporph yrin, in which the 3-carbons of the propanoyl groups are each covalently bound to a quaternary amine, and iron or cobalt is bound to the pyrrole nitrogens of the porphyrin. The oxygen carrier also includes a ligand L for protecting the open face of the porphyrin from .mu.-oxo dimer formation.
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Portions of the research conducted in support of the present invention were sponsored by the National Institutes of Health, Grant No. GM17880.
Collman James P.
Uffelman Erich S.
Zhang Xumu
Bond Robert T.
Dehlinger Peter J.
Powers Vincent M.
The Board of Trustees of the Leland Stanford Junior University
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