Tetraphenylbacteriochlorin derivatives and compositions...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C536S017100, C536S017400, C536S018500

Reexamination Certificate

active

11219853

ABSTRACT:
Provided is a tetraphenylbacteriochlorin derivative represented by the formula (I):[wherein R1, R2, R3and R4, independently from each other, are a residue of a monosaccharide represented by the formulae:(wherein, R is a hydrogen or a protecting group)], or its salt. The tetraphenylbacteriochlorin derivative or its salt has a large molar extinction coefficient at long wavelengths which are expected to have a high tissue-penetrating property, and exhibits high selectivity to tumor cells and hydrophilicity.

REFERENCES:
patent: 2000-007693 (2000-01-01), None
patent: WO-96/13504 (1996-05-01), None
R.P. Bonar-Law et al., J. Chem. Soc., Chem. Commun., pp. 456-458 (1993).
N. Datta-Gupta et al., J. Org. Chem., vol. 36, No. 14, pp. 2019-2021 (1971).
L. Gong et al., Can. J. Chem., vol. 63, pp. 401-405 (1985).
X. Zhang et al., Journal of Molecular Catalysis A: Chemical, vol. 154, pp. 31-38 (1999).
Y. Mitaka et al., Tetrahedron Letters, vol. 39, pp. 4505-4508 (1998).
H.W. Whitlock et al., Journal of the American Chemical Society, vol. 91, No. 26, Dec. 17, 1969, pp. 7485-7489.

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