Tetrapeptides as antitumor agents

Details Tetrapeptides as antitumor agents Tetrapeptides as antitumor agents

1996-07-30

1999-08-17

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

4 to 5 amino acid residues in defined sequence

514 18, C07K 500

Patent

active

059395273

ABSTRACT:
The present invention provides anti-tumor peptides of Formula I,

REFERENCES:
patent: 4816444 (1989-03-01), Pettit et al.
patent: 5502032 (1996-03-01), Haupt et al.
patent: 5504191 (1996-04-01), Pettit et al.
patent: 5530097 (1996-06-01), Pettit et al.
patent: 5554725 (1996-09-01), Pettit
patent: 5599902 (1997-02-01), Pettit et al.
HCAPLUS, AN 1996: 457934, Pettit et al., WO 9614856, May 23, 1996, abstract.
HCAPLUS, AN 1996: 756324, Sakakibara et al., WO 9633212, Oct. 24, 1996, abstract.
Pettit, G. R., et al., "Antineoplastic Agents 337. Synthesis of Dolastatin-10 Structural Modifications," Anti-Cancer Drug Design, 10: 529-544 (1995).
Miyazaki, K., et al., "Synthesis and Antitumor Activity of Novel Dolastatin-10 Analogs," Chem. Pharm. bull., 43 (10) : 1706-1718 (1995).
Pettit, G. R., et al., "The Isolation and Structure of a Remarkable Marine Animal Antineoplastic Constituent: Dolastatin 10", J. Am. Chem. Soc. 109: 6883-6885 (1987).
Bai, R., et al., "Structure-Activity Studies with Chiral Isomers and with Segments of the Antimitotic Marine Peptide Dolastatin 10", Biochemical Pharmacology 40 (8) : 1859-1864 (1990).
Pettit, G. R, et al., "Antineoplastic Agents. 220. Synthesis of Natural (-) --Dolastatin 15", J. Am. Chem. Soc., 113: 6692-6693 (1991).
Pettit, G. R., et al., "Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15", J. Org. Chem., 54: 6005-6006 (1989).
Pettit, G.R. et al., "Isolation of Dolastatins 10-15 From the MarineMollusc Dolabella Auricularia," Tetrahedron, 49(41) : 9151-9170 (1993).
Pettit, G.R. et al., "The Dolastatins 20. A Convenient Synthetic Route to Dolastatin 15," Tetrahedron, 50 (42) : 12097-12108 (1994).
Bai, R., et al., "Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects on cellular microtubules", 1-Pharmacology Abstract 117: 103735g P. 41 (1992).
Pettit, G. R., et al., "Isolation and Structure of the Cytostatic Depsipeptide Dolastatin 13 from the Sea Hare Dolabella auricularia", J. Am. Chem. Soc., 111 (13) : 5015-5017 (1989).

Affiliated with

Also associated with

Rating

Tetrapeptides as antitumor agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tetrapeptides as antitumor agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tetrapeptides as antitumor agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-315769