Tetrapeptidehydrazide derivatives

Details Tetrapeptidehydrazide derivatives Tetrapeptidehydrazide derivatives

1979-10-31

1981-07-07

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, C07G 700, A61K 3700

Patent

active

042773946

ABSTRACT:
Novel tetrapeptidehydrazide derivatives, inclusive of a pharmacologically acceptable acid addition salt thereof, which has the general formula (I): ##STR1## [wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 is hydrogen or the side chain of a D-.alpha.-amino acid; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen, or a saturated or unsaturated and straight or branched lower aliphatic acyl group which may optionally be substituted by hydroxy, amino, lower alkoxy, halogen, oxo, lower alkylthio or lower alkylthiooxide], are useful as analgesics.

REFERENCES:
Dutta, A. S., et al., Life Sciences, vol. 21, pp. 559-562, 1977.
Coy, D., et al., Biochem. Biophys. Res. Comm., vol. 73, pp. 632-637, 1976.
Pert, A., Opiates and Endogenous Opioid Peptides, pp. 87-94, 1976.
Walker, J., et al., Science, vol. 196, pp. 85-87, 1977.
Roemer, D., et al., Nature, vol. 268, 547-549, 1977.
Belluzzi, J., et al., Life Sciences, vol. 23, pp. 99-104, 1978.
Bazusz, S., et al., FEBS Letters, vol. 76, pp. 91-92, 1977.
McGregor, W. H., et al., Life Sciences, vol. 23, pp. 1371-1378, 1978.

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