Tetrapeptide stimulating the functional activity of...

Details Tetrapeptide stimulating the functional activity of... Tetrapeptide stimulating the functional activity of...

2006-09-05

2006-09-05

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S330000

Reexamination Certificate

active

07101854

ABSTRACT:
The invention refers to the field of medicine and may be applied as a substance stimulating the functional activity of hepatocytes, restoring the synthesis of non-specific proteins, normalising metabolism activating the processes of proliferation and differentiation of the liver cells. There is proposed a new compound -tetrapeptide lysyl-glutamyl-aspartyl-alanine of the general formula Lys-Glu-Asp-Ala [SEQ ID NO:1]. There is proposed a pharmaceutical composition capable of stimulating the functional activity of hepatocytes and a pharmaceutical peptide substance containing as its active base a therapeutically effective quantity of tetrapeptide of the formula Lys-Glu-Asp-Ala [SEQ ID NO:1] or one of its salts intended for parenteral administration. There is proposed a method of stimulating the functional activity of hepatocytes including therapeutic administration to a patient of the pharmaceutical peptide substance in doses 0.01–100 μg/kg of the body weight at least once a day during a period required for attaining a therapeutic effect.

REFERENCES:
H. Sponsel et al., “Mechanisms of Recovery from Mechanical Injury of Cultured Rat Hepatocytes”,Am. J. Physiol.,pp. C721-727 (1996).
H. Sponsel et al., “Mechanisms of Recovery From Mechanical Injury of Rental Tubular Epithelial Cells”,Am. J. Physiol. ,267, pp. F257-F264 (1994).
V. Khavinson, “Tissue—Specific Effects of Peptides”,Exper. Biol. and Med.132(2), pp. 807-808 (2001).

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