Tetrapeptide methyl ketone inhibitors of viral proteases

Details Tetrapeptide methyl ketone inhibitors of viral proteases Tetrapeptide methyl ketone inhibitors of viral proteases

1984-09-10

1987-03-24

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

A61K 3702

Patent

active

046525521

ABSTRACT:
Certain peptide methyl ketone derivatives inhibit picornavirus replication by inhibition of virus-specified protease activity.

REFERENCES:
patent: 4511504 (1985-04-01), McCullagh et al.
Lozitskii et al., Usp. Sovrem. Biol. 93:352 (1982).
Korant, J. Virol. 10:751 (1972).
Summers et al., J. Virol. 10:880 (1972).
Korant et al., PNAS USA 76:2992 (1979).
Powers, "Halomethyl Ketone Inhibitors of Proteolytic Enzymes," in Weinstein, ed., Chemistry and Biochemistry of Amino Acids, Peptides, and Proteins, (Dekker, New York, 1977) pp. 65-178.
Powers et al., Biochim. Biophys. Acta 480:246 (1977).
Ito et al., Biochem. Biophys. Res. Comm. 49:343 (1972).
Fittkau et al., Peptides 1982 p. 617 (1983).
Enzyme Systems Products (product bulletin, Nov. 1981).

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