Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1978-11-27
1979-12-11
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, A61K 3700, C07C10352
Patent
active
041783719
ABSTRACT:
Tetrapeptide amides of the formula ##STR1## wherein R.sup.1, R.sup.8, R.sup.x, B and D represent certain specified substituent groups. The compounds exhibit pharmacological activity when tested in vitro in the transmurally stimulated guinea pig ileum preparation indicating their affinity for opiate receptor sites, and also in vivo tests, with intravenous administration, indicating their analgesic effects, and hence their utility as analgesic agents.
REFERENCES:
Yamashiro, et al., Biochem. and Biophys. Res. Commun., 78, 1977, pp. 1124-1129.
Phillips Delbert R.
Reckitt & Colman Products Limited
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