Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-03-07
2006-03-07
Campell, Bruce R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S330000
Reexamination Certificate
active
07008928
ABSTRACT:
The invention provides crystals of N2-(N,N-dimethyl-L-valyl)-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-1-pyrrolidinyl]-1-[(S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide or salts thereof which possess potent antitumor activity and methods for their preparation.
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K. Miyazaki et al., “Synthesis and Antitumor Activity of Novel Dolastatin 10 Analogs”, Chem. Phar. Bull., vol. 43, No. 10, pp. 1706-1718, 1995.
G. R. Pettit et al., “The Doplastatins. 21. Synthesis, X-ray Crystal Structure, and Molecular Modeling of (6R)-Isodolastatin 101a”, The Journal of Organic chemistry, vol. 59, No. 21, Oct. 21, 1994, pp. 6127-6130.
Kanada Arihiro
Keino Katsuyuki
Minami Nobuyoshi
Miyazaki Koichi
Campell Bruce R.
Kosar Andrew D.
Teikoku Hormone Mfg. Co. Ltd.
Wenderoth , Lind & Ponack, L.L.P.
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