Tetrapeptide .alpha.-ketoamides

Details Tetrapeptide .alpha.-ketoamides Tetrapeptide .alpha.-ketoamides

1996-12-27

1998-06-09

Huff, Sheela

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

4 to 5 amino acid residues in defined sequence

514 17, 514 18, C07K 500, C07K 700, C07K 1700, A61K 3800

Patent

active

057635765

ABSTRACT:
A novel class of tetrapeptide .alpha.-ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula M.sub.1 --AA.sup.1 --AA.sup.2 --AA.sup.3 --AA.sup.4 --CO--NR.sub.3 R.sub.4.

REFERENCES:
patent: 5371072 (1994-12-01), Webb
patent: 5496927 (1996-03-01), Kolb
patent: 5541290 (1996-07-01), Harbeson
patent: 5597804 (1997-01-01), Webb
Conforth, et al., Journal of the Chemical Society, pp. 93-98 (1953).

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