Tetrapeptide adamantyl amides

Details Tetrapeptide adamantyl amides Tetrapeptide adamantyl amides

1984-04-16

1985-04-30

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, C07C10352

Patent

active

045143323

ABSTRACT:
This invention relates to novel tetrapeptide adamantyl amides that are useful in the treatment of hypertension.

REFERENCES:
patent: 4273704 (1981-06-01), Mazur
Goodman and Gilman, The Pharmacological Basis of Therapeutics, (New York, 1975), Fifth Edition, Chaps. 26, 27, 28, 30, 33, 39, 40.
Poulsen, Burton, and Haber, "Competitive Inhibitors of Renin; Biochemistry, 12, 3877-3882 (1983).
Burton, Cody, Herd, and Haber, "Specific Inhibition of Renin by An Angiotensinogen Analog . . . ", Proc. Natl. Acad. Sci. USA, 77, 5476-5479, (1980).
Cody, Burton, Evin, Poulsen, Herd, and Haber, "A Substrate Analog Inhibitor of Renin That Is Effective In Vivo," Biochem. Biophys. Res. Commun., 97, 230-235, (1980).
Burton, Poulsen, and Haber, "Competitive Inhibitors of Renin . . . ", Biochemistry, 14, 3892-3898, (1975).
Haas, Lewis, Scipione, and Koshy, "Micromethod for the Assay of Renin of Seven Species," Hypertension, 1, 112-117, (1979).

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