Tetrapeptide

Details Tetrapeptide Tetrapeptide

1998-04-10

1999-11-30

Moezie, F. T.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

435180, 530330, 530324, 530812, 530815, 530811, 514 12, 514 13, 514 14, 514 15, 514 16, 514 17, 514 18, C12N 1108, C07K 500, C07K 1702

Patent

active

059945010

ABSTRACT:
The peptide X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys, or other amino acid, having the same cell-attachment activity as fibronectin and the peptide X-Arg-Gly-Asp-Ser-Y, wherein X and Y, having said activity are disclosed.

REFERENCES:
patent: 3883393 (1975-05-01), Knazek et al.
patent: 4511653 (1985-04-01), Play et al.
patent: 4517686 (1985-05-01), Ruoslahti
patent: 4578079 (1986-03-01), Ruoslahti
patent: 4589881 (1986-05-01), Pierschbacher et al.
patent: 4792525 (1988-12-01), Ruoslahti
patent: 5041380 (1991-08-01), Ruoslahti et al.
patent: 5278063 (1994-01-01), Hubbell et al.
Hynes, et al. Cell surface fibronectin and oncogenic transformation. J. Supramolecular Structure 11:95-104(1979).
Hahn, Lian-Hsien E. and Kenneth M. Yamada. Isolation and biological characterization of active fragments of the adhesive glycoprotein fibronectin. Cell 18:1043-1051, 1979.
Sekiguchi, Kiyotoshi and Sen-Itiroh Hakomori. Functional domain structure of fibronectin. Proc. Natl. Acad. Sci. 77:2661-2665.
Grinnell, Frederick, et al. Distribution of fibronectin during wound healing in Vivo. J. Invest. Dermatol. 76:181-189, 1981.
McDonagh, R.P., et al. Amino acid sequence of the factor XIII.sub.a acceptor site in bovine plasma fibronectin. Febs Letters. 127:174-178, 1981.
Ruoslahti, Erkki, et al. Alignment of biologically active domain in the fibronectin molecule. J. Biol. Chem. 256:7277-2781, 198-.
Pande, Hema, et al. Comparative structural studies of human plasma and amniotic fluid fibronectins. Bioch, Biophy, Res. Comm.101:265-272, 1981.
Pande, Hema and John E. Shively. NH.sub.2 -terminal sequences of DNA-heparin-, and gelatin-binding tryptic fragments from human plasma fibronectin. Arch Bioch. Biophy. 213:258-265, 1982.
Pierschbacher, Michael D., et al. The cell attachment domain fibronectin. J. Biol. Chem. 257:9593-9597, 1982.
Seitz, T.L. and K.D. Noonan. Effect of fibronectin on the adhesion of an established cell line to a surface reactive bio material. J. Biomed. Mat. Res. 16:195-207, 1982.
Vibe-Pedersen, Karen, et al. Amino acid sequence of a peptide from bovine plasma fibronectin containing a free sulfhydryl (cysteine). Febs. Letters 142:26-30, 1982.
Sekiguchi, Kiyotoshi, et al. Monoclonal antibodies directed to two different domains of human plasma fibronectin: Their specificities. Fed. Eur. Bich. Soc. 142:243-246, 1982.
Ehrismann, Ruth, et al. Arrangement of attachment-promoting, self-association, and heparin-binding sites in horse serum fibronectin. J. Biol. Chem. 257:7381-7387, 1982.
Clark, Richard A.F., et al. Fibronectin is produced by blood vessels in response to injury. J. Exp. Med. 156:646-651 1982.
Hynes, Richard O. and Kenneth M. Yamada. Fibronectins: Multifunctional modular glycoproteins. J. Cell. Biol. 95:369-377, 1982.
Petersen, Torbene, et al. Partial primary structure of bovine plasma fibronectin: Three types of internal homology. Proc. Natl. Acad. Sci. 80:137-141, 1983.
Grinnell, Frederick. Cell attachment and spreading factors in Growth and Maturation Factors (Dr. Gordon Guroff, Ed.) John Wiley & Sons, Inc., 1983.
Grinnell, Frederick. The role of fibronectin in the bioreaction of material surfaces in Biocompatible Polymers, Metals, and Composites. (Ed. Michael Szycher). Technomic Publishing, Lancaster, Pennsylvania 1983.
Hayashi, Masao and Kenneth M. Yamada. Domain structure of the carboxyl-terminal half of human plasma fibronectin. J. Biol. Ch 258:3332-3340, 1983.
Kornblihtt, Alberto R., et al. Isolation and characterization of cDNA clones for human and bovine fibronectins. Proc. Natl. Acad. Sci. 80:3218-3222, 1983.
Pierschbacher, Michael, et al. Synthetic peptide with cell attachment activity of fibronectin. Proc. Natl. Acad. Sci. 80:1224-12 1983.
Grinnell et al., Cell, 19:517-525 (1980).
Bernard et al., Biochemistry, 22:5213-5223 (1983).
Seyer et al., Biochem., 20:2621-2727 (1981).

Affiliated with

Also associated with

Rating

Tetrapeptide does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tetrapeptide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tetrapeptide will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1674096