Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-05-10
1995-05-30
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142355, 514343, 514414, 548544, 548511, 548469, 548454, 546281, 544 82, 544124, 544131, 544141, C07D207273, A61K 3140
Patent
active
054201551
ABSTRACT:
A class of 4-hydroxy-2(1H)-pyrrolone derivatives, substituted at the 3-position by an optionally substituted aryl substituent, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA receptor antagonist.
REFERENCES:
patent: 3931207 (1976-01-01), Weinstock
patent: 3984559 (1976-10-01), Weinstock
CA86(9):55276a Compositions . . . Arthritis, Weinstock p. 424, 1977.
Kulagowski Janusz J.
Leeson Paul D.
Mawer Ian M.
DiPrima Joseph F.
Lee Mary C.
McKane Joseph K.
Merck Sharp & Dohme Ltd.
North Robert J.
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