Tetralones with pharmacological activity, compositions containin

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514336, 514277, 546330, 546268, 546340, A61K 3144, C07D21389

Patent

active

053569156

ABSTRACT:
The present invention relates to new tetralones having formula I: ##STR1## wherein R.sup.1 to R.sup.7 are as defined in claim 1. The invention also relates to processes for their preparation, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments. These compounds are antihypertensive and bronchodilator agents.

REFERENCES:
patent: 5132307 (1992-07-01), Baumgarth et al.
patent: 5208246 (1993-05-01), Almansa et al.
R. W. Griffin, J. D. Gass, M. A. Berwick, R. S. Shulman, J. Org. Chem., 1964, 29, 2109.
Chemical Abstracts, vol. 85, No. 19, 8 Nov. 1976, abstract No. 142883u, V. P. Barve et al., Indian J. Chem., Sect. B., vol. 14B, No. 2 (1976), pp. 84-87.
Chemical Abstracts, vol. 65, No. 1, 4 Jul. 1966, abstract No. 665d, G. Traverso et al., Farmaco Ed. Sci., vol. 21, No. 1 (1966), pp. 35-50.
European Search Report dated Feb. 2, 1994 for corresponding European patent application No. 93107289.6.

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