Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-01-20
2000-04-11
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142295, 514247, 514255, 514278, 514325, 514326, 514357, 514408, 514409, 514411, 514423, 514595, 514617, 514623, 514682, 514684, 544359, 544361, 544368, 544380, 546 15, 546 16, 546 79, 546203, 546205, 546285, 548407, 548427, 548528, 548530, 548579, 564 47, 564173, 564180, 568326, 568328, 568330, A61K 31445, C07D21132
Patent
active
060488778
ABSTRACT:
Tetralone derivatives of the formula ##STR1## where R.sup.1 is halo, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, (aryl)alkenyl, (aryl)alkynyl, alkoxy, O-alkenyl, O-aryl, O-alkyl(heterocyclo), COO-alkyl,alkanoyl, CO-amino, CO-substituted amino, alkyl-CO-amino, alkyl-CO-substituted amino, NHCO-alkyl, NHCO-aryl, NHCO-alkyl(heterocyclo), N(alkyl)CO-alkyl, N(alkyl)CO-aryl, N(alkyl)CO-heterocyclo, N(alkyl)CO-alkyl(heterocyclo);
REFERENCES:
patent: 4785006 (1988-11-01), Worthington et al.
patent: 5439914 (1995-08-01), Claremon et al.
patent: 5847159 (1998-12-01), Kai et al.
Bhattacharya et al. CA 100:156040, 1984.
Zelle et al. CA 126:74618, 1996.
Kai et al. CA 126:47121, 1996.
Shrivastavas et al. CA 125:10328, 1996.
Mitrenga et al. CA 123:25145, 1995.
Gueremy et al. CA 115:232233, 1991.
Defraine et al: CA 107:96452, 1986.
IBM CA 106:175963, 1986.
Worthington et al. CA 106:115236, 1986.
Kanao et al. CA 103:178258, 1985.
Cross et al. CA 99:105247, 1983.
Kulkarni et al. CA 97:109663, 1982.
Welch et al. CA 88:115083, 1978.
Welch et al. CA 87:67028, 1977.
Brown et al. CA 75:88829, 1971.
Schoenenberger et al. CA 72:65748, 1969.
Setnikar et al. "Cardiovascular and other pharmacologic . . . " CA 66:54082, 1966.
Hernestam et al. "Treating cardiac arrhythmia . . . " CA 87:90726, 1976.
Parke et al. "Cis-2,6-dimethyl-. . . " CA 87:84839, 1976.
Petersen et al. "Experimental anti-arrhythmic . . . " CA 89:209056, 1978.
Chan "2-substituted tetralin derivatives . . . " CA 107:228448, 1987.
Chan et al. "A partially rigid butyrophenone . . . " CA 108:94178, 1986.
Loza et al. "Antiserotoninergic activity of 2-aminoethylbenzocyclanones . . . " CA 119:85437, 1993.
Kato et al. "Preparation of 2-aminoalkyltetralines . . . " CA 129:216428, 1998.
Selnick, H.G. et al, "Class III Antiarrhythmic Activity in vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I.sub.Ks by (R)-2-(2,4-Trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3 -dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide", J. Med. Chem., 40(24), 3865-3868, 1997.
Nair, L.A. et al, "Emerging Class III Antiarrhythmic Agents: Mechanism of Action and Proarrhythmic Potential", Cardiovascular Drugs and Therapy 1997; 11:149-167.
Ahmad Saleem
Atwal Karnail S.
Ferrara Francis N.
Stein Philip D.
Bristol--Myers Squibb Company
Chang Ceila
Rodney Burton
LandOfFree
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