Tetralone-based monoamine reuptake inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C564S428000, C564S454000, C564S456000, C560S028000, C514S510000, C514S647000, C514S657000

Reexamination Certificate

active

08053603

ABSTRACT:
The invention relates to novel tetralone based amines and their use in the treatment of central nervous system (CNS) disorders, such as depression, attention deficit hyperactivity disorder (ADHD) and Parkinson's disease. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods of inhibiting reuptake of one or more monoamine, such as such as dopamine and norepinephrine, from the synaptic cleft, and methods of modulating one or more monoamine transporter.

REFERENCES:
patent: 3663608 (1972-05-01), Holava et al.
patent: 4540690 (1985-09-01), Szmuszkovicz
patent: 4587258 (1986-05-01), Gold et al.
patent: 4738709 (1988-04-01), Nielsen
patent: 4751231 (1988-06-01), Halczenko et al.
patent: 4981870 (1991-01-01), Koe
patent: 5091429 (1992-02-01), Begue et al.
patent: 5225596 (1993-07-01), Carlsson et al.
patent: 5373018 (1994-12-01), Cugola et al.
patent: 5374649 (1994-12-01), Cugola et al.
patent: 5523278 (1996-06-01), Wepplo
patent: 5550255 (1996-08-01), Urbach et al.
patent: 5578627 (1996-11-01), Takeda et al.
patent: 5620997 (1997-04-01), Bolton et al.
patent: 5668162 (1997-09-01), Domagala et al.
patent: 5686461 (1997-11-01), Cugola et al.
patent: 5859042 (1999-01-01), Lee et al.
patent: 5962496 (1999-10-01), Cugola et al.
patent: 5965591 (1999-10-01), Kojima et al.
patent: 6096771 (2000-08-01), Kojima et al.
patent: 6100289 (2000-08-01), Cugola et al.
patent: 6331636 (2001-12-01), Romero et al.
patent: 6372919 (2002-04-01), Lippa et al.
patent: 6399601 (2002-06-01), Du Bois
patent: 6479527 (2002-11-01), Barker et al.
patent: 6576653 (2003-06-01), Du Bois
patent: 6589949 (2003-07-01), Moriwaki et al.
patent: 6603000 (2003-08-01), Yee et al.
patent: 6828460 (2004-12-01), Browning et al.
patent: 6995144 (2006-02-01), Ozaki et al.
patent: 7166725 (2007-01-01), Fang et al.
patent: 7226938 (2007-06-01), Cai et al.
patent: 7488747 (2009-02-01), Fang et al.
patent: 7579370 (2009-08-01), Heffernan et al.
patent: 7615572 (2009-11-01), Fang et al.
patent: 2002/0010198 (2002-01-01), Jerussi et al.
patent: 2002/0085976 (2002-07-01), Elomari
patent: 2002/0123490 (2002-09-01), Howard, Jr.
patent: 2002/0183369 (2002-12-01), Du Bois
patent: 2003/0087803 (2003-05-01), Yatvin et al.
patent: 2003/0171440 (2003-09-01), Senanayake et al.
patent: 2003/0195361 (2003-10-01), Du Bois
patent: 2003/0215523 (2003-11-01), Ozawa et al.
patent: 2004/0048878 (2004-03-01), Cai et al.
patent: 2004/0092605 (2004-05-01), Jerussi et al.
patent: 2004/0106681 (2004-06-01), Rao et al.
patent: 2004/0220229 (2004-11-01), Bussolotti et al.
patent: 2005/0020645 (2005-01-01), Ohta et al.
patent: 2005/0089935 (2005-04-01), Cai et al.
patent: 2005/0143434 (2005-06-01), Fang et al.
patent: 2005/0143443 (2005-06-01), Fang et al.
patent: 2006/0019944 (2006-01-01), Wu et al.
patent: 2006/0229286 (2006-10-01), Kakigami et al.
patent: 2006/0235002 (2006-10-01), Nagai et al.
patent: 2007/0100135 (2007-05-01), Riggs et al.
patent: 2007/0142452 (2007-06-01), Banner et al.
patent: 2007/0203111 (2007-08-01), Shao et al.
patent: 2008/0004327 (2008-01-01), Heffernan et al.
patent: 2008/0004328 (2008-01-01), Dorsey et al.
patent: 2008/0058395 (2008-03-01), Heffernan et al.
patent: 2009/0005456 (2009-01-01), Shao et al.
patent: 2009/0099248 (2009-04-01), Heffernan et al.
patent: 2009/0149549 (2009-06-01), Zhao et al.
patent: 2010/0016397 (2010-01-01), Fang et al.
patent: 2010/0022612 (2010-01-01), Dorsey et al.
patent: 2010/0029737 (2010-02-01), Heffernan et al.
patent: 2010/0029741 (2010-02-01), Dorsey et al.
patent: 2010/0120740 (2010-05-01), Heffernan et al.
patent: 616646 (1962-05-01), None
patent: 2033323 (1991-01-01), None
patent: 2066593 (1992-02-01), None
patent: 2410077 (2001-11-01), None
patent: 2474451 (2003-08-01), None
patent: 2498152 (2004-03-01), None
patent: 2498175 (2004-03-01), None
patent: 2565852 (2005-11-01), None
patent: 2566094 (2005-12-01), None
patent: 1106386 (1995-08-01), None
patent: 1709871 (2005-12-01), None
patent: 1962656 (2007-05-01), None
patent: 1124485 (1962-03-01), None
patent: 3431541 (1986-03-01), None
patent: 0101786 (1984-03-01), None
patent: 0 399 982 (1990-11-01), None
patent: 0396124 (1990-11-01), None
patent: 1136071 (2001-09-01), None
patent: 1219603 (2002-07-01), None
patent: 1262181 (2002-12-01), None
patent: 1362864 (2003-11-01), None
patent: 1088824 (2004-01-01), None
patent: 1391460 (2004-02-01), None
patent: 1420028 (2004-05-01), None
patent: 2081747 (1996-03-01), None
patent: S54-059269 (1979-05-01), None
patent: H01-016786 (1989-01-01), None
patent: H01-172388 (1989-07-01), None
patent: H04-077476 (1992-03-01), None
patent: WO 86/00896 (1986-02-01), None
patent: WO 90/15047 (1990-12-01), None
patent: WO 92/06967 (1992-04-01), None
patent: WO 95/17381 (1995-06-01), None
patent: WO 98/42709 (1998-10-01), None
patent: WO 99/10343 (1999-03-01), None
patent: WO 99/18065 (1999-04-01), None
patent: WO 99/40913 (1999-08-01), None
patent: WO 99/40914 (1999-08-01), None
patent: WO 99/48868 (1999-09-01), None
patent: WO 99/58490 (1999-11-01), None
patent: WO 00/07978 (2000-02-01), None
patent: WO 00/25770 (2000-05-01), None
patent: WO 01/02427 (2001-01-01), None
patent: WO 01/27103 (2001-04-01), None
patent: WO 01/79208 (2001-10-01), None
patent: WO 02/12249 (2002-02-01), None
patent: WO 02/20530 (2002-03-01), None
patent: WO 02/31128 (2002-04-01), None
patent: WO 03/016302 (2003-02-01), None
patent: WO 03/039540 (2003-05-01), None
patent: WO 03/063797 (2003-08-01), None
patent: WO 03/074531 (2003-09-01), None
patent: WO 03/074532 (2003-09-01), None
patent: WO 03/091213 (2003-11-01), None
patent: WO 03/092670 (2003-11-01), None
patent: WO 2004/022537 (2004-03-01), None
patent: WO 2004/031193 (2004-04-01), None
patent: WO 2004/031194 (2004-04-01), None
patent: WO 2004/039787 (2004-05-01), None
patent: WO 2004/041780 (2004-05-01), None
patent: WO 2004/089470 (2004-10-01), None
patent: WO 2004/113345 (2004-12-01), None
patent: WO 2005/013981 (2005-02-01), None
patent: WO 2005/018637 (2005-03-01), None
patent: WO 2005/020986 (2005-03-01), None
patent: WO 2005/020987 (2005-03-01), None
patent: WO 2005/046575 (2005-05-01), None
patent: WO 2005/066135 (2005-07-01), None
patent: WO 2005/066143 (2005-07-01), None
patent: WO 2005/089753 (2005-09-01), None
patent: WO 2005/123677 (2005-12-01), None
patent: WO 2006/001958 (2006-01-01), None
patent: WO 2006/004040 (2006-01-01), None
patent: WO 2006/021000 (2006-02-01), None
patent: WO 2006/077412 (2006-07-01), None
patent: WO 2007/039773 (2007-04-01), None
patent: WO 2007/068621 (2007-06-01), None
patent: WO 2007/081542 (2007-07-01), None
patent: WO 2007/081857 (2007-07-01), None
patent: WO 2007/115185 (2007-10-01), None
patent: WO 2008/005456 (2008-01-01), None
patent: WO 2008/089453 (2008-07-01), None
patent: WO 2008/151156 (2008-12-01), None
patent: WO 2009/020814 (2009-02-01), None
patent: WO 2010/017418 (2010-02-01), None
Database CAPLUS on STN, Acc. No. 1977:83511, KOE, Journal of Pharmacology and Experimental Therapeutics (1976), 199(3), p. 649-661 (abstract).
Braga et al., Chem. Commun. (2005), 29, p. 3635-3645.
Database CAPLUS on STN, Acc. No. 1993:233604, Bertolini et al., European Journal of Medicinal Chemistry (1992), 27(7), p. 663-672 (abstract).
Database CAPLUS on STN, Acc. No. 1955:28047, Mikhailov et al., Sbornik Statei po Obshchei Khimii (1953), 2, p. 1085-1086 (abstract).
Abarbri et al., “Les beta-cétonitriles groupes protecteurs de la fonction amine. Préparation d'amino-alcools”, Helv. Chim. Acta 1995, 78(1), 109-121.
Aboul-Enein et al., “Synthesis and Antiemetic Profile of N-[1-[(diethylamino)methyl]cyclohexyl]amides”, Sci. Pharm. 1990, 58(3), 273-280.
Alvaro et al., “Preparation and photolysis of diaryl esters of acetylenedicarboxylic acid”, Tetrahedron 1992, 48(16), 3437-3444.
Ando et al., “3-(Arylacetylamino)-N-methylbenzamides: A Novel Class of Selective Anti-Helicobacter pylori Agents”, J. Med. Chem. 2001, 44(25), 4468-4474.
Arya et al., “Synthesis of New Heterocycles: Part XV. Synthes

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Tetralone-based monoamine reuptake inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tetralone-based monoamine reuptake inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tetralone-based monoamine reuptake inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4268006

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.