Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Reexamination Certificate
2006-10-03
2006-10-03
Kumar, Shailendra (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
C514S480000, C514S534000, C514S535000, C514S577000, C514S616000, C514S617000, C564S155000, C564S180000, C562S511000, C560S043000, C560S128000
Reexamination Certificate
active
07115767
ABSTRACT:
The present invention is related to compounds of formula (I),or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.
REFERENCES:
patent: 5238955 (1993-08-01), Brunner et al.
patent: 5362878 (1994-11-01), Chang et al.
patent: 5436261 (1995-07-01), Cordi et al.
patent: 5656634 (1997-08-01), Chang et al.
patent: 2001956 (1979-02-01), None
patent: 56-57754 (1981-05-01), None
Abbady et al, J. Chem., U.A.R., 8, No. 1, 33-39(1965).
RN 5060-85-5, 1965.
Asakawa, A., et al., “Ghrelin Is an Appetite-Stimulatory Signal From Stomach With Structural Resemblance to Motilin”,Gastroenterology, 120:337-345 (2001).
Cummings, D.E., et al., “Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery”,The New England Journ. Of Med., 346(21):1623-1630 (2002).
Frohman, L. A., & Jansson, J-O., “Growth Hormone-Releasing Hormone”,Endocrine Reviews, 7(3):223-253 (1986).
Howard, A.D., et al., “A Receptorin Pituitary and Hypothalamus That Functions inGrowth Hormone Release”,Science, 273:974-977 (1996).
Kamegai, J., et al., “Central Effect of Ghrelin, an Endogenous Growth Hormone Secretagogue, on Hypothalamic Peptide Gene Expression”,Endocrinology, 141(12):4797-4800 (2000).
Kojima, M., et al., “Ghrelin is a growth-hormone-releasing acylated peptide from stomach”,Nature, 402:656-660 (1999).
Momany, F.A., et al., “Design, Synthesis, and Biological Activity of Peptides which Release Growth Hormonein Vitro”, Endocrinology, 108(1):31-39 (1981).
Murakami, N., et al., “Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats”,Journ of Endociniology, 174:283-288 (2002).
Nakazato, M., et al., “A role for ghrelin in the central regulation of feeding”,Nature, 409:194-198 (2001).
Shintani, M., et al., “Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway”,Diabetes, 50(2):227-232 (2001).
Shuto, Y., et al., “Hypothalamic growth hormone secretagogue receptor regulates ggrowth hormone secretion, feeding, and adiposity”,The Journ of Clin Invest., 109(11):1429-1436 (2002).
Svensson, J., et al., “Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure”,Journ of Clin Endocrin., 83(2):362-369 (1998).
Liu Bo
Liu Gang
Nelson Lissa T. J.
Patel Jyoti R.
Sham Hing L.
Abbott Laboratories
Corbin Johanna M.
Kumar Shailendra
Parial Andrew M.
LandOfFree
Tetraline derivatives as ghrelin receptor modulators does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tetraline derivatives as ghrelin receptor modulators, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tetraline derivatives as ghrelin receptor modulators will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3681700