Tetralin esters of phenols or benzoic acids having retinoid like

Details Tetralin esters of phenols or benzoic acids having retinoid like Tetralin esters of phenols or benzoic acids having retinoid like

1992-06-04

1993-07-27

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514513, 514533, 514538, 514541, 514544, 558254, 558255, 560 41, 560 44, 560 51, 560 60, 560 61, 560 81, 560 85, A61K 31235, C07C 6975, C07C 6982, C07C32726

Patent

active

052311139

ABSTRACT:
Retinoid-like activity is exhibited by compounds of the formula ##STR1## where the R groups are independently hydrogen, or lower alkyl; A is --C(O)O--, --OC(O)--, --C(O)S--, or --SC(O)--; n is 0-5; and Z is H, --COB where B is --OH or a pharmaceutically acceptable salt, or B is --OR.sub.1 where R.sub.1 is an ester-forming group, or B is --N(R).sub.2 where R is hydrogen or lower alkyl, or Z is --OE where E is hydrogen or an ether-forming group or --COR.sub.2 where R.sub.2 is hydrogen, lower alkyl, phenyl or lower alkyl phenyl, or Z is --CHO or an acetal derivative thereof, or Z is --COR.sub.3 where R.sub.3 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4 and the sum of n and m does not exceed 4.

REFERENCES:
patent: 4096341 (1978-06-01), Frazer
patent: 4391731 (1983-07-01), Boller et al.
patent: 4695649 (1987-09-01), Magami et al.
patent: 4810804 (1989-03-01), Chandraratna
patent: 4826969 (1989-05-01), Maignan et al.
patent: 4855320 (1989-08-01), Chatterjee et al.
Sporn et al. in J. Amer. Acad. Derm. 15:756-764 (1986).
Shudo et al., Chem. Phar. Bull., 33:404-407 (1985).

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