Tetralin compounds with improved MDR activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

5142372, 514315, 514318, 514330, 544129, 546153, 546192, 546193, 546194, 546146, C07D21700, C07D21100, A61K 3147, A61K 31445

Patent

active

057261849

ABSTRACT:
The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer.

REFERENCES:
patent: 5192773 (1993-03-01), Armistead et al.

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