Tetrahydrothiepino[4,5-d]imidazole derivatives, composition and

Details Tetrahydrothiepino[4,5-d]imidazole derivatives, composition and Tetrahydrothiepino[4,5-d]imidazole derivatives, composition and

1981-04-16

1983-05-10

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548323, A61K 31415, C07D49504

Patent

active

043829457

ABSTRACT:
Imidazole derivatives of the formula ##STR1## wherein X is hydrogen or C.sub.1-4 -alkyl, Y is sulfur, sulfinyl or sulfonyl and Z is thienyl, optionally substituted by methyl or fluorine, or a group of the formula ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are hydrogen, methyl, fluorine, hydroxy, methoxy, methylthio or two of R.sup.1, R.sup.2 and R.sup.3 on adjacent carbon atoms taken together are methylenedioxy or ethylenedioxy or one of R.sup.1, R.sup.2 and R.sup.3 is mono- or di-(C.sub.1-4 -alkyl)-amino and the other two are hydrogen,
and physiologically or pharmaceutically compatible or acceptable acid addition salts thereof, are described. The compounds of formula I inhibit the aggregation of the blood platelets and have antihyperglycemic activity.

REFERENCES:
patent: 3185691 (1965-05-01), Pribyl et al.
patent: 3615607 (1967-03-01), Soma et al.
De Groot et al., J. Org. Chem. 1966, vol. 31(12), pp. 3954-3958.
Wynberg et al., Chem. Abst. 1965, vol. 63, p. 5630e.
Corvers et al., Chem. Abst. 1974, vol. 80, No. 95830j.
Wynberg et al., Chem. Commun. 1965, No. 9, p. 171.

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