Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-06-24
1993-07-27
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514311, 514313, 514314, 546153, 546156, 546159, 546165, A61K 3147, C07D21536
Patent
active
052311023
ABSTRACT:
A class of 1,2,3,4-tetrahydroquinolines possessing at least one substituent, or a spirocyclic moiety, at the 4-position, and an acidic group or a group convertible thereto in vivo at the 2-position, are specific antagonists of N-methyl-D-aspartate (NMDA) receptors and are therefore useful in the treatment and/or prevention of neurodegenerative disorders.
REFERENCES:
Journal of Org. Chem. vol. 55, No. 2, pp. 738-741, 1990.
Chem. Absts. vol. 110, No. 19, 1989 p. 61.
Chem. Absts. vol. 70, No. 5 1969, p. 1997.
Baker Raymond
Carling William R.
Leeson Paul D.
Smith Julian D.
DiPrima Joseph F.
Merck Sharp & Dohme Ltd.
North Robert J.
Richter Johann
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