Tetrahydroquinoline derivatives and a process for preparing...

Details Tetrahydroquinoline derivatives and a process for preparing... Tetrahydroquinoline derivatives and a process for preparing...

2011-01-18

2011-01-18

Havlin, Robert (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C514S272000, C546S159000

Reexamination Certificate

active

07872126

ABSTRACT:
A novel compound of the formula (I):wherein R1is alkoxycarbonyl or the like, R2is alkyl or the like; R3is hydrogen or the like; R4is alkylene or the like; R5is optionally substituted heterocyclic group; R6, R7, R8and R9are independently hydrogen; alkyl, alkoxy, or the like; R10is optionally substituted aromatic ring, or the like; or a pharmaceutically acceptable salt thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP).

REFERENCES:
patent: 6147089 (2000-11-01), DeNinno et al.
patent: 6313142 (2001-11-01), Damon et al.
patent: 6489478 (2002-12-01), DeNinno et al.
patent: 2003/0216398 (2003-11-01), Kakihana et al.
patent: 2763590 (1998-11-01), None
patent: 2002053557 (2002-02-01), None
patent: WO 98/38194 (1998-09-01), None
patent: WO-00/17164 (2000-03-01), None
patent: WO-00/17165 (2000-03-01), None
patent: WO-00/17166 (2000-03-01), None
patent: WO 02/079165 (2002-10-01), None
patent: WO-03/063868 (2003-08-01), None
patent: WO-2006/012093 (2006-02-01), None
Kubinyi (3D QSAR in Drug Design: Ligand-Protein Interactions and Molecular Similarity, vol. 2-3, Springer, 1998, 800 pages).
Crousse et al., “Synthesis of 2-CF3-Tetrahydroquinoline and Quinoline Derivatives from CF3-N-Aryl-aldimine”, J. Org. Chem., vol. 65 (2000) pp. 5009-5013.
Hicks et al., “Differential effects of the novel non-peptidic opioid 4-tyrosylamido-6-benzyl-1,2,3,4 tetrahydroquinoline (CGPM-9) on in vitro rat t lymphocyte and macrophage functions”, Life Sciences, vol. 68, No. 24, pp. 2685-2694.
Japanese Office Action issued in Japanese application No. 2006-534487 on Feb. 23, 2010.
Katritzky et al., “Synthesis of Pyrido[4,3,2-de]quinazolines via Nitro-Substituted Tetrahydroquinolines”, J. Heterocyclic Chem., vol. 36, No. 3 (1999) pp. 755-759.
Kondo et al., “Formation of Pyrido [3,2,-f]quinoxalines by Reaction of 6-Amino-2, 3-dimethylquinoxaline with Aldehydes”, Chem. Pharm. Bull., vol. 45, No. 4, (1997) pp. 722-724.
Wang et al., “Design of a High Affinity Peptidomimetic Opioid Agonist from Peptide Pharmacophore Models”, Bioorganic & Medicinal Chemistry Letters, vol. 8 (1998) pp. 2685-2688.

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