Tetrahydropyridinyl indoles

Details Tetrahydropyridinyl indoles Tetrahydropyridinyl indoles

1979-01-10

1981-07-14

Raymond, Richard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546273, A61K 31445, C07D40104

Patent

active

042786770

ABSTRACT:
Novel tetrahydropyridinyl indoles of the formula ##STR1## wherein R' is selected from the group consisting of hydrogen, halogen and alkoxy of 1 to 3 carbon atoms, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms and X' is selected from the group consisting of alkyl of 1 to 6 carbon atoms, cycloalkyl of 4 to 7 carbon atoms, alkenyl and alkynyl of 2 to 5 carbon atoms and aralkyl of 7 to 12 carbon atoms with the proviso that when X' is methyl, at least one of R', R.sub.1 and R.sub.2 contain more than one carbon atom and when X' is benzyl, at least one of R', R.sub.1 and R.sub.2 must not be hydrogen and their non-toxic, pharmaceutically acceptable acid addition salts having antidepressive and neuroleptic properties as well as antiemetic properties.

REFERENCES:
patent: 2872453 (1959-02-01), Jacob et al.
patent: 3429886 (1969-02-01), Beck et al.
patent: 3501484 (1970-03-01), Schut et al.
patent: 3980658 (1976-09-01), Possanza et al.
patent: 3993764 (1976-11-01), Dumont et al.
patent: 4196209 (1980-04-01), Dumont et al.
Freter, J. Org. Chem., vol. 40, No. 17, (1975) pp. 2527-2529.

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