Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-06-23
2004-10-05
Davis, Zinna Northington (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S307000, C546S081000, C546S139000
Reexamination Certificate
active
06800638
ABSTRACT:
The invention relates to tetrahydropyridine derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-cell-proliferation activity such as anti-cancer activity and are accordingly useful in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said tetrahydropyridine derivatives, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cell-proliferation effect in a warm-blooded animal such as man.
BACKGROUND OF THE INVENTION
Transcriptional regulation is a major event in cell differentiation, proliferation, and apoptosis. Transcriptional activation of a set of genes determines cell destination and for this reason transcription is tightly regulated by a variety of factors. One of its regulatory mechanisms involved in the process is an alteration in the tertiary structure of DNA, which affects transcription by modulating the accessibility of transcription factors to their target DNA segments. Nucleosomal integrity is regulated by the acetylation status of the core histones. In a hypoacetylated state, nucleosomes are tightly compacted and thus are nonpermissive for transcription. On the other hand, nucleosomes are relaxed by acetylation of the core histones, with the result being permissiveness to transcription. The acetylation status of the histones is governed by the balance of the activities of histone acetyl transferase (HAT) and histone deacetylase (HDAC). Recently, HDAC inhibitors have been found to arrest growth and apoptosis in several types of cancer cells, including colon cancer, T-cell lymphoma, and erythroleukemic cells. Given that apoptosis is a crucial factor for cancer progression, HDAC inhibitors are promising reagents for cancer therapy as effective inducers of apoptosis (Koyama, Y., et al., Blood 96 (2000) 1490-1495).
Several structural classes of HDAC inhibitors have been identified and are reviewed in Marks, P. M., J. Natl. Cancer Inst. 92 (2000) 1210-1216. More specifically, WO 98/55449 and U.S. Pat. No. 5,369,108 report alkanoyl hydroxamates with HDAC inhibitory activity.
It has now been found that certain tetrahydropyridine derivatives possess anti-cell-proliferation properties which are more potent than those in the aforementioned references. These properties are due to HDAC inhibition.
REFERENCES:
patent: 5369108 (1994-11-01), Breslow et al.
patent: WO 90/02119 (1990-03-01), None
patent: WO 98/07421 (1998-02-01), None
patent: WO 98/15525 (1998-04-01), None
patent: WO 98/55449 (1998-12-01), None
Hoffman et al., Nucleic Acids Research, 27, pp. 2057-2058 (1999).
Marks et al., J. Natl. Cancer Institute, 92, pp. 1210-1216 (2000).
Graf von Roedern et al., J. Med. Chem., 41, pp. 3041-3047 (1998).
Koyama et al., Blood, 96, pp. 1490-1495 (2000).
Hoshino et al., The Chemistry of Heterocyclic Compounds, 38, pp. 225-543 (1995).
Cox et al., Chem. Rev., 95, pp. 1797-1842 (1995).
Georges Guy
Grossman Adelbert
Mundigl Olaf
Sattelkau Tim
von der Saal Wolfgang
Davis Zinna Northington
Hoffman-La Roche Inc.
Johnston George W.
Rocha-Tramaloni Patricia S.
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