Tetrahydropyridine and piperidine derivatives

Details Tetrahydropyridine and piperidine derivatives Tetrahydropyridine and piperidine derivatives

1984-09-13

1986-07-15

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514337, 546196, 546269, A61K 31445, C07D40504

Patent

active

046007199

ABSTRACT:
Compounds of the class of (2-benzofuranyl)-1,2,3,6-tetrahydropyridines and (2-benzofuranyl)-piperidines which at the ring nitrogen atom are unsubstituted or substituted by a substituent of the class of certain aliphatic, cycloaliphatic and araliphatic radicals, and their pharmaceutically acceptable acid addition salts have valuable pharmacological properties. In particular, they inhibit monoamine oxidase and antagonise the action of tetrabenazine. They are useful as active ingredients for therapeutic compositions for the treatment of mental depression. Specific embodiments are 4-(2-benzofuranyl)-piperidine, 2-(5,6-dimethyl-2-benzofuranyl)-piperidine and their hydrochlorides.

REFERENCES:
Ziegler et al., Chim. Ther. vol. 6, 1971, pp. 159-166.

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