Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-05-13
2008-05-13
Wilson, James O. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S469000, C546S001000, C544S242000
Reexamination Certificate
active
11294657
ABSTRACT:
The present invention relates to a group of novel tetrahydropyridin-4-yl indoles with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine-D2receptors, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said tetrahydropyridin-4-yl indoles. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect.The invention relates to novel tetrahydropyridin-4-yl indoles of the formula.and tautomers, stereoisomers, prodrugs, N-oxides, pharmacologically acceptable salts, hydrates and solvates thereof,wherein:R1is hydrogen, halogen, alkyl(C1-3) or alkoxy(C1-3), CN or CF3,R2is hydrogen or alkyl(C1-3),R3is hydrogen or alkyl(C1-3),Z is hydrogen or alkyl(C1-3), alkoxy(C1-3) or alkylthio(C1-3),A is hydrogen or alkyl(C1-3), orA and Z together form a saturated or (partly) unsaturated 5- or 6-membered ring which may be substituted with halogen, alkyl (C1-3) or phenyl, in which ring Z represents carbon, sulfur of nitrogen.
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Hes Roelof van
Kruse Cornelis G.
Smid Pieter
Tulp Martinus Th. M.
Finnegan Henderson Farabow Garrett & Dunner
Solvay Pharmaceuticals B.V.
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