Tetrahydropyrid-4-yl-chroman-5-ol derivatives in the treatment o

Details Tetrahydropyrid-4-yl-chroman-5-ol derivatives in the treatment o Tetrahydropyrid-4-yl-chroman-5-ol derivatives in the treatment o

1975-08-20

1977-03-08

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424858, 424267, 424274, A61K 3140, A61K 3144, A61K 31445, A61K 31535

Patent

active

040113299

ABSTRACT:
Compounds of the formula: ##STR1## and their pharmaceutically acceptable non-toxic salts, wherein R.sub.1 is alkyl of 5 to 8 carbon atoms which is straight chained or .alpha.-substituted by a methyl group or .alpha.,.alpha.-disubstituted by methyl groups and R.sub.5 is hydrogen, R.sub.6 or CO.R.sub.6 wherein R.sub.6 is alkyl of 1 to 4 carbon atoms or alkyl of 1 to 4 carbon atoms substituted by NR.sub.7 R.sub.8 wherein R.sub.7 and R.sub.8 are each hydrogen or alkyl of 1 to 4 carbon atoms or NR.sub.7 R.sub.8 is pyrrolidino, piperidino or morpholino, have been found to possess good antihypertensive activity while being of low-toxicity and substantially free of sedative side effects.

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