Tetrahydropyrid-4-yl-chroman-5-ol derivatives

Details Tetrahydropyrid-4-yl-chroman-5-ol derivatives Tetrahydropyrid-4-yl-chroman-5-ol derivatives

1974-09-09

1976-06-01

Randolph, John D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

42463, 42466, 260297B, C07D21168

Patent

active

039608808

ABSTRACT:
Compounds of the formula: ##SPC1##
And their pharmaceutically acceptable non-toxic salts, wherein R.sub.1 is alkyl of 5 to 8 carbon atoms which is straight chained or .alpha.-substituted by a methyl group or .alpha.,.alpha.-disubstituted by methyl groups and R.sub.5 is hydrogen, R.sub.6 or CO.R.sub.6 wherein R.sub.6 is alkyl of 1 to 4 carbon atoms or alkyl of 1 to 4 carbon atoms substituted by NR.sub.7 R.sub.8 wherein R.sub.7 and R.sub.8 are each hydrogen or alkyl of 1 to 4 carbon atoms or NR.sub.7 R.sub.8 is pyrrolidino, piperidino or morpholino, have been found to possess good antihypertensive activity while being of low-toxicity and substantially free of sedative side effects.

REFERENCES:
patent: 3707474 (1972-12-01), Razdan et al.
patent: 3726883 (1973-04-01), Razdan et al.
patent: 3853899 (1974-12-01), Fake

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