Tetrahydropyran derivatives and their use as therapeutic agents

Details Tetrahydropyran derivatives and their use as therapeutic agents Tetrahydropyran derivatives and their use as therapeutic agents

2007-09-04

2007-09-04

Solola, Taofiq (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S326000, C514S460000, C544S107000, C546S207000, C548S407000, C548S529000, C549S416000

Reexamination Certificate

active

10488842

ABSTRACT:
The present invention relates compounds of the formula (I); wherein R1, R2, R3, R4, R5, R6, R7, R8, and R10represent a variety of substituents; A represents NR9or O; B represents a bond, CH2, NR9or O, wherein one or both hydrogen atoms in said CH2moiety may be replaced with one or both of R7and R8, or alternatively, one of the hydrogen atoms in said CH2moiety together with a hydrogen atom from an adjacent carbon are replaced by a double bond; with the proviso that when A is O, then B is NR9; n is zero, 1 or 2; and pharmaceutically acceptable salts thereof. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia

REFERENCES:
patent: 6071927 (2000-06-01), Baker et al.
patent: 2002/0035132 (2002-03-01), Williams et al.
patent: WO 0056727 (2000-09-01), None
patent: WO03/022839 (2003-03-01), None

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