Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-10-31
1995-11-28
Haley, Jacqueline
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514285, 544125, 546 71, A61K 31435, C07D22118
Patent
active
054708524
ABSTRACT:
A tetrahydroprotoberberine quaternary ammonium compound represented by the formula: ##STR1## wherein R.sub.1, R.sub.2, R' and X are as defined in the specification. A method of preparing the compound is provided. The compounds can suppress arrhythmia and ventricular fibrillation, protect against myocardial ischemia, and can be conveniently orally administered.
REFERENCES:
Wang Y. X. et al. Acta Pharmacological Sinica (1987) 8(3):220-223.
Xu Z. et al. Acta Pharmacologica Sinica (1989) 110(4):320-324.
Wang Y. et al. Acta Pharmacologica Sinica (1990) 11(5):422-427.
Tanaka S. et al. Chemical Abstracts (1979), 90:138075t.
Dai Dezai
Huang Wenlong
Huang Zhenya
Peng Sixun
Wang Youqun
Administrative Center of New Drug Research, The State Pharmaceut
China Pharmaceutical University
Haley Jacqueline
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