Tetrahydronapthalene derivatives and their therapeutic use

Details Tetrahydronapthalene derivatives and their therapeutic use Tetrahydronapthalene derivatives and their therapeutic use

1997-09-05

2000-10-17

Fonda, Kathleen K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 41, 536 179, A61K 3170, C07H 1500

Patent

active

061332402

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is a fucose or mannose residue, have therapeutic utility via inhibition of selectins, and thus of cell adhesion.

REFERENCES:
Singh, Sheo Bux, and George R. Pettit (Oct., 1990) "Antineoplastic Agents, 195. Isolation and Structure of Aceratioside From Aceratium megalopsermum" Journal of Natural Products, 53(5):1055-1397.
Paulson "Carbohydrate Ligands of Leukocyte Adhesion Molecules and Their Therapeutic Potential" in Progess in Brain Research 1994, 101, 179-184, Chapter 13. Months not available.
Levy et al. "Cell Adhesion and Carbohydrates" in Annual Reports in Medicinal Chemistry 1994, 29, 215-224, Chapter 22. Month is not available.

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