Tetrahydronaphthalene derivatives and preparation thereof

Details Tetrahydronaphthalene derivatives and preparation thereof Tetrahydronaphthalene derivatives and preparation thereof

1990-10-30

1993-04-27

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560 10, 564 92, C07C31726

Patent

active

052064280

ABSTRACT:
A tetrahydronaphthalene derivative of the formula: ##STR1## wherein R.sup.1 is a substituted or unsubstituted phenyl group, naphthyl group, a sulfur- or nitrogen-containing heterocyclic group, a lower alkyl group or cycloalkyl group, and R.sup.2 is hydroxymethyl group, carboxyl group, a lower alkoxycarbonyl group or a group of the formula: ##STR2## wherein R.sup.3 is hydrogen atom or a lower alkyl group, R.sup.4 is a lower alkoxycarbonyl-phenyl group, carboxy-phenyl group, a lower alkyl group, a lower alkoxycarbonyl-lower alkyl group or carboxy-lower alkyl group, and m and n are different and are 1 or 2, or a pharmaceutically acceptable salt thereof, which are useful as a platelet aggregation-inhibiting agent and as an agent for the treatment, amelioration and/or prophylaxis of a variety of thrombosis or embolism, coronary and cerebral vascular smooth muscle vellication, asthma, and the like, processes for the preparation thereof, and pharmaceutical composition containing said compound as an active ingredient.

REFERENCES:
patent: 4868331 (1989-09-01), Niewohner et al.
patent: 4868332 (1989-09-01), Niewohner et al.
patent: 4886898 (1989-12-01), Niewohner et al.
Hanasaki et al., Biochem. Pharmac., vol. 38, No. 12, pp. 2007-2017 (1989).
Bush et al, Thrombosis Research, vol. 44, pp. 377-389 (1986).
Lumley et al, Br. J. Pharmac., vol. 97, pp. 783-794 (1989).

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