Tetrahydronaphthalene derivatives

Details Tetrahydronaphthalene derivatives Tetrahydronaphthalene derivatives

1985-10-10

1987-07-14

Lone, Werren B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514475, 514512, 514518, 514524, 514654, 514682, 514721, 514732, 549359, 549362, 549433, 549437, 549440, 549443, 558 58, 558269, 560152, 560153, 560154, 564355, 564360, 568632, 568633, 568634, 568736, H61K 3124, C07D31744, C07D31914, C07C14920, C07C 6900, C07C 3917, C07C 4318, C07B 9308

Patent

active

046803106

ABSTRACT:
Tetrahydronaphthalene derivatives of the formula ##STR1## wherein Y, m, n, R and R.sup.1 to R.sup.9 are as set forth herein, are described.
These compounds have a pronounced calcium-antagonistic and anti-arrhythmic activity and can accordingly be used as medicaments, especially for the control or prevention of angina pectoris, ischaemia, arrhythmias and high blood pressure. The compounds of formula I can be prepared by the amination of a compound of the formula ##STR2## with a corresponding N-methyl-phenylalkylamine and optional subsequent O-acylation. Compounds of formula II and IV are also described and are within the scope of the invention.

REFERENCES:
patent: 3957845 (1976-05-01), Trelber et al.
patent: 4127588 (1978-11-01), Ramuz

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