Tetrahydronaphthalene derivatives

Details Tetrahydronaphthalene derivatives Tetrahydronaphthalene derivatives

1994-08-17

1997-07-01

Bond, Robert T.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

540455, 530321, 544335, 546326, 549 79, 549484, 562433, C07K 754, C07K 400, C07D28500

Patent

active

056440243

ABSTRACT:
The present invention is concerned with tetrahydronaphthalene derivatives which are mimics of domains of peptides or proteins which can interact with other proteins or with DNA or RNA through .alpha.-helical conformation, said tetrahydronaphthalene derivatives having the formulae: ##STR1## are valuable aids in the determination of biologically active peptide sequences and are accordingly so-called "research tools". They are, however, also potentially suitable as medicaments.

REFERENCES:
Chen, et al., Biochemistry, 11, No. 22: pp. 4120-4131, (1972).
Chen and Kane, Biochemistry, 13, No. 16, pp. 3330-3335 (1974).
Callahan, et al, Tetrahedron, vol. 49, No. 17 pp. 3479-3488 (1993).
Callahan, et al, J. Med. Chem. vol. 35, pp. 3970-3972 (1992).

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